That’s the main problem. In 1995, the journal Medical Hypotheses printed a hypothesis by Dr. Lit-Hung Leung, a physician from Hong Kong, which attempted to link vitamin B5 (pantothenic acid) deficiency with acne formation.1 Then, in 1997, the Journal of Orthomolecular Medicine printed an article by Dr. Leung on the same topic.2 The hypothesis was just that, a hypothesis - an initial suggested explanation, in this case without any reputable studies to back up the claim. Perhaps there’s another way B5 works. Orthomolecular medicine is the discredited idea that you can use megadoses of vitamins to cure many diseases. It seems like I need to watch my diet as well and avoid high glycemic foods and high carbohydrate foods to help stave off acne. I don’t understand why it stops to work. The results were shocking, to put it mildly. The group with acne is the one that has not enough of pantothenic acid in the body, whereas in the other group, pantothenic acid levels are not deficient. The doctor said that commonly the hair dies to spare other organs needing the scarce nutrients more during such periods of deficiency. Generally, speaking there is some research showing some benefits from some herbs. If B5 works, I’m sure it’s because of some other mechanism than the one proposed by Dr. Leung. Feel free to check it out and make sure I don’t take anything out of context. Of course, you can continue arguing about why didn’t he provide proof for his trial, etc, etc, but again, something not published does not mean it is wrong. We will explain the role of Vitamin B5 in the metabolism of fats and oils, and how increasing the metabolism of oils will reduce oil accumulation in the skin, and thereby reduce or eliminate acne. Do you have acne on your back and/or chest? It has no effect on my acne, but eating onions causes a huge breakout the next day. My guess that you can get hair loss at super high doses by depleting cysteine. I translate pharmaceutical and biotech patents (I’m a chemist). Because the body uses coenzyme A for hormone production instead of fatty acid metabolism, sebum (skin oil) levels rise and acne follows. The really short answer is that AcneEase is probably pure BS. I’ve lived with my skin for a long time, so I could certainly tell that this was a very different healing pattern for me. Why would the body waste this precious resource producing excess sex hormones? B Vitamin Mega Doses and Skin Breakouts Clinical case studies by physicians have demonstrated that mega doses of particular B vitamins can cause acne rosacea, regular acne, oily skin, flushing and skin redness. Case reports and some much earlier non-controlled studies describe a lack of acute or chronic toxic effects of pantothenic acid compounds (calcium or sodium pantothenate, panthenol) at very high doses (approximately 10,000 mg/day in some cases for a number of years), although such levels have been associated with diarrhoea and gastrointestinal disturbances. In short, this study is littered with holes.". Address All the evidence you are giving to refute his study is about how X and Y INCREASES sebum. All it does it to show that ANOTHER factor is at work that causes the cells to produces sebum (For the sake of the argument, lets call this factor A). I seriously wonder what was going on his head as he wrote that sebum secretion is wasting precious energy resources. And that hormones increase sebum production at the skin and that this has really nothing to do with serum (blood) fatty acids. Deficiency. The study was done in a hospital dedicated to studying Traditional Chinese Medicine. So in my case I take B5, AND Coenzyme A, and I drink a lot of water and try to avoid taking in too many carbs and avoid high glycemic foods. If B5 actually was effective, do you think dermatologists who make a killing off of this disease and the companies at large are in a rush to throw away a multi-billion dollar industry over night? I accept no advertisements. This sounds like a claim that’s easy to test. I wonder if some people have a genetic defect that they just dont process b5 and cysteine correctly when making CoA? I suspect you have to restore the depleted pools of CoA and once that happens you can just have a maintenance dose. There are probably a lack of studies on the effectiveness of B5 because there’s no incentive to do so. . Anytime I read a testimonial I sort of mentally connect with the person and think it’s me getting the results. User reviews are generally very positive. Well it has for me anyway. Hopefully they may have done in another 15 years time. I’m willing to try anything at this point! E.g. So, in desperation I went to acne forums and found out about Dr. Leung’s thesis and have never looked back since. The most frequent dermatologic manifestations of androgen excess are hirsutism, acne, and androgenic alopecia. Like most ingredients in the realm of skincare, the correlation between vitamin B5 and acne, and whether or not the former is an effective treatment for the latter, begs a lot more research. We also have the studies that show impressive reductions in sebum production with topical application of ‘androgen blockers’ (such as green tea and evening primrose oil). Now using Panthethine to try and find a long term effect but again it works for a limited time. When treating acne, it is important to avoid irritation.. In my mind a far more credible explanation for this whole thing is motivated reasoning from Dr. Leung’s part. The theory of treating acne with megadoses of vitamin B5 supplements is based on a rather sketchy hypothesis paper published by a Chinese researcher Dr. Lit-Hung Leung. About hair loss – it’s possible that coincidence is at work. They haven’t tested different ratios of those herbs. And testimonials are massively unreliable. What do u think is happening? YouTube and Instagram are popular places to share, but anywhere is fine :-). Like most ingredients in the realm of skincare, the correlation between vitamin B5 and acne, and whether or not the former is an effective treatment for the lat Everything You Need to Know About Vitamin B5 for Acne … He has a very strong reason to believe his theory is correct. I’ve had my blood checked a few times and at least B12 and folate are within the normal range. 9 July 2009. Have you ever trief pantothenic acid to reduce the acne on your oily face from slow metabolism?? I don’t underster why do you recommend buying B5 + N-acetylcysteine, if you can buy Pantethine itself? They showed that 50 – 60% of the effect is due to placebo. Most credible sources say vitamin B5 is safe even in high doses, though again we have anecdotal reports of hair loss and even severe side-effects. That’s argument from authority. I still get pimples here and there but it definitely helps. The journal’s scientific standards may be less than rigorous. 1 Jan 2008. Please help spread the word about The Acne.org Regimen by telling a friend who could benefit or using social media to share your success. He’s just saying that he did a study and we are supposed to believe him. But there is anecdotal evidence of hair loss and even severe, very long lasting side-effects. I also think that B5 interacts with other B vitamins. Why not produce just what’s needed and save some CoA for fat metabolism? You can read more about my journey through acne and how I eventually ended up creating this. One could always plead to some unknown factor at play. If you want something that’s more likely to work, I recommend you check out this post. 3. My personal opinion is that for most people b5 plus n acetyl cysteine will work. N-acetylcysteine has been shown to be quite effective against acne. He stated that external androgens don’t affect sebum production. There are currently no official recommendations as to what dosage of vitamin B-5 you should take to treat acne. For example, let me quote one of your arguments: “If that’s the case, then why sex hormones levels are elevated in acne patients? While you may see companies marketing vitamin B5 to acne sufferers, your time and … It works by attacking the root cause which is the oil in the skin. Of course, there are simple assumptions the author makes that need not be explained word for word, because he assumes the reader is smart enough to figure it out. I found it in my mid 40s and I am 60 now and get compliments on my skin. When lipids are deposited in the sebaceous glands and excreted as sebum secretion, it does suggest some abnormality is going on and hint that some form of fat metabolism may be at fault. I just cannot believe that medical science cannot cure acne. Again, we can’t say for sure from anecdotes. I was completely clear for 7 months. Eureka Skincare It works! As I mentioned in the previous comment he has never established that B5 deficiency exists and that it indeed does limit metabolism of fatty acids, which then leads to excessive sebum production. It’s a shame more people don’t know about it and are suffering with acne! But when the proposed hypothesis contradicts both observations and our current understanding (derived from those observations), then what reason I have to believe into the proposed hypothesis? Acne.org does not advertise. Or the inconvenient fact that sex hormone levels are often elevated in acne patients. But it was done by Neutraceuticals Medical Research, a company that conducts outsources medical research for natural health companies. But where is that study. Thank you for working so hard to compile all of this information for us acne sufferers. Except that again facts don’t agree with him. Exogenous (externally derived) androgens do cause acne. Regardless of the cause, overproduction of either T or T precursors leads to exaggerated T action in target tissues such as skin. Feel free to explore . Whereas studies from other countries, mostly Western, showed much more realistic results. That they indeed do affect sebum production the same way that endogenous androgens do. thank you for good info, if you know of ways to help with the blemishes would greatly appreciate it, I have published over 100 posts on this blog about that. This agrees with the hormonal nature of acne, but not with Dr. Leung’s theory. The body does by largely maintaining the functionally more important reaction, while at the same time slowing down the lesser important one. If you read my other posts you’ll see I’ve covered many of them. Totally recommend it, But many have reported side effects so I would recommend starting at a Low Does with some Anti Oxidants. We see the same thing in acupuncture research. Unfortunately user reviews are just about the most unreliable form of evidence there is. I wonder why Dr. Leung hasn’t bothered to test this, as it seems like a very easy way to support his theory. Puolikkotie 802230 EspooFinland, Vitamin B5 (Pantothenic Acid) For Acne – Skeptical View. Let me explain: 1. This seems utterly ridiculous to me, and none of the diet acne studies support this. But what you are really doing is special pleading away contradicting evidence. Like most ingredients in the realm of skincare, the correlation between vitamin B5 and acne, and whether or not the former is an effective treatment for the latter, begs a lot more research. But that in itself doesn’t prove really anything yet. If you have read the paper more carefully, I think you dont understand what he’s getting at (I think you must see the forest for the trees, instead of nitpicking on these small details). Though there’s no scientific evidence of harm, there are anecdotal reports of severe side-effects after vitamin B5 megadoses. That is Pantothene + pantothenic acid plus n-acetyl cysteine. Do red/dark marks from previous acne linger on your skin? The only thing I regret is not knowing about it when I was a teenager. I hope this information will help others out there suffering from this awful condition. In skin, T is converted to DHT by the enzyme 5a-R, which acts directly on hair follicles and the sebaceous glands. There are many ways to rig a study to show what you want. And it specifically mentions the brand Panthothen in the paper, so I’m assuming the company sponsored it. My acne never returned after one treatment. It looks to me he started with the end goal in mind and tried to ‘prove’ it in his paper. Lack of studies doesn’t mean anything itself, and there are anecdotal reports that B5 helps with acne – though many say it works for some months and then acne comes back. And that the more rigorous the study was the more the likely it was to be negative. I adjust it based on what I call the “forehead test”. Vitamin B5's correlation with healthy, clear skin doesn't stop at the bottles and tinctures lining your vanity, however. Everything You Need to Know About Vitamin B5 for Acne. Yikes high dosages. Improvement was presented in general terms. Pantothenic acid (vitamin B5), Dexpanthenol. I’ve tried everything as well including lazor surgery. It definetely worked for me when I tried it. Actually, I think you are mistaken about the way science handles new claims. To make educated conclusions, double-blind, controlled research will be required. As a topical skincare ingredient, vitamin B5 … For me it worked. So we have no way to know anything about the study. Any new theory on acne has to take into account all this existing experimental evidence. He clearly states in his hypothesis paper that androgen hormones don’t cause acne or increase sebum production. I can only tell about my experience. One difference is that I happened to weigh about 20 lbs more than I do now. Alt-med people commonly criticize drug companies for doing that. Nothing. In the same paper Dr. Leung talks about his own study with 100 acne patients. He refers to no studies that show that restricting B5 intake increases sebum production – or vice versa. I wouldn’t completely discount this guy. Just as cancer is not one disease, but can be classified into 9 different types; It could be likely that acne could be something similar, and these diseases manifests themselves as skin acne. That’s why testimonials work. 100% Ad-free. Furthermore, prior to publishing his hypothesis paper he applied and received a US patent for B5 acne treatment. The doctor used these doses and found them effective but, this was a clinical trial. Nothing cured it. It took a month or maybe longer, but his face cleared up to almost nothing! I don’t know why it works, but it does. I’m just commenting based on what they write on their website. But the patent would be proof of “I was first”. Side effects seem low and tolerable. I have had little to no Oil on my Skin and my breakouts are not even that big of a breakout. Quite hard to know what to make of stories like yours. But the possibility of it existing doesn’t mean it does exist. No evidence of toxicity. The dear doctor says that acne is not linked to sex hormones but rather to deficiency in Coenzyme A. its just painful being an acne sufferer, try it out, its working for me and its a price i can afford to buy constantly. It’s not complete bull. As lots of drug makers can tell you, many drugs that work in cell cultures wont work properly if given to a human being. In the grand scheme of things 28 GBP every 6 weeks is not that bad. Vitamin B5 has also been recognised to help with more chronic conditions such as cystic acne, eczema and rosacea as it enhances the healing process of the skin and reduces blemishes.” Best of luck to you, and I’m happy to provide more details if needed. The recommendation was 1500 B5 with 1200 mg n- acetylcysteine. Ha! Regardless, it’s a ridiculously shaky ground to build a scientific hypothesis on. I have used b5 on and off for years, it 100% works for a limited time. [ December 2, 2020 ] Ducas scores 19, Saint Mary’s tops Nicholls 73-50 Sports [ December 2, 2020 ] Everything You Need to Know About Vitamin B5 for Acne Fashion [ December 2, 2020 ] Iowa … Given that it was created because other, reputable journals refused to publish their papers. This paper doesn’t. Dr. Leung never published his study he bases this on, so we have no way to know. I don’t know how well it will work long-term, but I am enjoying 95% clear skin while I can. We also can’t rule out a placebo effect. I think a lot of people don’t 1) take high enough of a dose for it to work 2) wait long enough for it to work. The only time I ever have a flare up is if I skip a dose (ie, falling asleep before taking it, running out of pills, laziness). There is a known mechanism that explains increased sebum production in acne. Finally, if you wish for the most benefit, then try and find a health … i am quite happy to say vit b5 works….and if you are an acne sufferer, you know what its like to always feel uncomfortable, embarrassed, insecure and your confidence levels take a dive!!!! So unless there’s evidence for it you probably shouldn’t say “carbs cause it”. You have to give it time for it to get into your body and start working. But I think I’ve made the point. Forgot to check the box on follow up comments. A month or two ago a new study came out that showed B5 supplementation actually reduced acne. What evidence has he provided for this? If that’s the case, then why sex hormones levels are elevated in acne patients? There is no credible research to show pantothenic acid megadosing is helpful in acne. It’s just an unfortunate reality for those of us who have to live with ‘acne genes’. We can explain this through the effect insulin has on the skin, but not though CoA. Second, the study ran only for 30 days. The fact is, there is no known cure to completely erradicate the disease. I didn’t look into research on any of the ingredients. These are simple things that need not be explained word for word, because it’s assumed the reader is smart enough to figure it out. The fact that he graduated from a prestigious university doesn’t in itself mean anything. The choice here is a relatively simple one. Interesting article, First off, I was on Accutane due to SEVERE ANCE about 3 years ago, it cleared up my skin but 3 months after I finished, it all came back with vengeance. While what you say could be applicable to drug companies, I don’t think the same could be said of dermatologists and doctors. This leaves less CoA available for lipid (fat) metabolism. Finally, nowhere in the paper did Dr. Leung say anything about acne being a disease or that it would have a genetic component. Whenever taking extra of one B vitamin, it’s generally recommended to also take the whole B complex as a supplement at the same time. Deeper pimples around the nose, mouth … This should be very easy to demonstrate first in cell culture studies and then in animal studies where B5 intake is restricted. It’s possible B5 helps your acne, but we just can’t say for sure. While you may see companies marketing vitamin B5 to acne sufferers, your time and money is better spent on reliable acne treatments. While in fact I only learned about his patent much later on. Instead of taking 5 500mg every 2 hours, I’m going to take 4 500mg every 3.5 hours. All it does it to show that ANOTHER factor is at work that causes the cells to produces sebum (For the sake of the argument, lets call this factor A). This sub introduced me to vitamin B5/pantothenic acid, as well as African black soap, and it's done wonders for me. Family members and friends have also had good results (with nowhere near megadosing). 2.The theory is about coenzyme A helping to REDUCE (metabolize) the sebum, not produce it. I am happy to say my skin is generally always at 90-100% acne free. Oily skin seems to be the common thread for people who get good results from B5. As I mentioned in the post, he applied and received a patent for B5 acne treatment before his paper was published. And my evidence included more than just cell culture studies, which alone are not sufficient. He refers to no studies that shows that B5 limits fat metabolism and so increases sebum production. Sucrose has a direct financial interest in turning this into a combative argument results ’ in. Carbs cause it ” that none of this means AcneEase doesn ’ t deterred acne?. Sure they would probably get better, but starts to feel bumpy, the lesions come right back text.! A stone that kills two birds: how pantothenic acid “ I was 34-35 1500 B5 N-acetylcysteine. 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